Flexify Advanced Joint Supplement – Clinical Research

  1. Jean-Yves Reginster, Audrey Neuprez, Marie-Paule Lecart, Nathalie Sarlet, and Olivier Bruyere. Role of glucosamine in the treatment for osteoarthritis. Rheumatol Int. 2012 Oct; 32(10): 2959–2967.
  2. Bruyère. Pharmaceutical-grade chondroitin sulfate in the management of knee osteoarthritis. Expert Opin Pharmacother. 2018 Mar;19(4):409-412.
  3. Martel-Pelletier J, Raynauld JP, Mineau F, Abram F, Paiement P, Delorme P, Pelletier JP. Levels of serum biomarkers from a two-year multicentre trial are associated with treatment response on knee osteoarthritis cartilage loss as assessed by magnetic resonance imaging: an exploratory study. Arthritis Res Ther. 2017 Jul 20;19(1):169.
  4. Hochberg M, Chevalier X, Henrotin Y, Hunter DJ, Uebelhart D. Symptom and structure modification in osteoarthritis with pharmaceutical-grade chondroitin sulfate: what's the evidence?
  5. Curr Med Res Opin. 2013 Mar;29(3):259-67.
  6. Hochberg, M.C. Structure-modifying effects of chondroitin sulfate in knee osteoarthritis: an updated meta-analysis of randomized placebo-controlled trials of 2-year durationOsteoarthritis and Cartilage, 2010 June; 18 (1): S28-S31.
  7. Kim LS, Axelrod LJ, Howard P, Buratovich N, Waters RF. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis and Cartilage. 2006 Mar;14(3):286-94.
  8. Usha PRNaidu MU. Randomised, Double-Blind, Parallel, Placebo-Controlled Study of Oral Glucosamine, Methylsulfonylmethane and their Combination in Osteoarthritis. Clin Drug Investig. 2004;24(6):353-63.
  9. Notarnicola A, Maccagnano G, Moretti L, Pesce V, Tafuri S, Fiore A, Moretti B. Methylsulfonylmethane and boswellic acids versus glucosamine sulfate in the treatment of knee arthritis: Randomized trial. Int J Immunopathol Pharmacol. 2016 Mar;29(1):140-6.
  10. Eric D. Withee, Kimberly M. Tippens, Regina Dehen, Deanne Tibbitts, Douglas Hanes, and Heather Zwickey. Effects of Methylsulfonylmethane (MSM) on exercise-induced oxidative stress, muscle damage, and pain following a half-marathon: a double-blind, randomized, placebo-controlled trial. J Int Soc Sports Nutr. 2017; 14:24.
  11. Krishanu Sengupta, Krishnaraju V Alluri, Andey Rama Satish, Simanchala Mishra, Trimurtulu Golakoti, Kadainti VS Sarma,Dipak Dey and Siba P Raychaudhuri. A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin® for treatment of osteoarthritis of the knee. Arthritis Research & Therapy 2008; 10:R85.
  12. Y. Henrotin, A.L.Clutterbuck, D. Allaway, E.M. Lodwig, P. Harris, M. Mathy-Hartert, M. Shakibaei. Biological actions of curcumin on articular chondrocytes. Osteoarthritis and Cartilage 2010 Feb.; 18(2) 141-149. 
  13. Binu Chandran, Ajay Goel. A Randomized, Pilot Study to Assess the Efficacy and Safety of Curcumin in Patients with Active Rheumatoid Arthritis 2012, Mar.
  14. E.M. Bartels, V.N. Folmer, H. Bliddal, R.D. Altman, C. Juhl, S.Tarp, W. Zhang, R. Christensen. Efficacy and safety of ginger in osteoarthritis patients: a meta-analysis of randomized placebo-controlled trials. Osteoarthritis and Cartilage 2015; 23(1): 13-21
  15. Søren Ribel-Madsen, Else Marie Bartels, Anders Stockmarr, Arne Borgwardt, Claus Cornett, Bente Danneskiold-Samsøe, and Henning Bliddal. A Synoviocyte Model for Osteoarthritis and Rheumatoid Arthritis: Response to Ibuprofen, Betamethasone, and Ginger Extract—A Cross-Sectional In Vitro Study. Arthritis 2012; 505842.
  16. Gatenby P, Lucas R, Swaminathan A. Vitamin D deficiency and risk for rheumatic diseases: an update. Curr Opin Rheumatol. 2013 Mar; 25(2):184-91.
  17. Goula T, Kouskoukis A, Drosos G, Tselepis AS, Ververidis A, Valkanis C, Zisimopoulos A, Kazakos K. Vitamin D status in patients with knee or hip osteoarthritis in a Mediterranean country. J Orthop Traumatol. 2015 Mar;16(1):35-9.
  18. Laslett LL, Quinn S, Burgess JR, Parameswaran V, Winzenberg TM, Jones G, Ding C. Moderate vitamin D deficiency is associated with changes in knee and hip pain in older adults: a 5-year longitudinal study. Ann Rheum Dis. 2014 Apr;73(4):697-703.
  19. Jansen JA, Haddad FS. High prevalence of vitamin D deficiency in elderly patients with advanced osteoarthritis scheduled for total knee replacement associated with poorer preoperative functional state. Ann R Coll Surg Engl. 2013 Nov;95(8):569-72. 
  20. Veronese N, Maggi S, Noale M2 De Rui M, Bolzetta F, Zambon S, Corti MC, Sartori L, Musacchio E, Baggio G, Perissinotto E, Crepaldi G, Manzato E, Sergi G. Serum 25-Hydroxyvitamin D and Osteoarthritis in Older People: The Progetto Veneto Anziani Study. Rejuvenation Res. 2015 Dec;18(6):543-53.
  21. Rosecrans R, Dohnal JC. Seasonal vitamin D changes and the impact on health risk assessment. Clin Biochem. 2014 May;47(7-8):670-2.
  22. Laura Tripkovic, Helen Lambert, Kathryn Hart, Colin P Smith, Giselda Bucca, Simon Penson, Gemma Chope, Elina Hyppönen, Jacqueline Berry, Reinhold Vieth, and Susan Lanham-New. Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis. Am J Clin Nutr. 2012 Jun; 95(6): 1357–1364.
  23. Manoy P, Yuktanandana P, Tanavalee A, Anomasiri W, Ngarmukos S, Tanpowpong T, Honsawek S. Vitamin D Supplementation Improves Quality of Life and Physical Performance in Osteoarthritis Patients. Nutrients 2017 Jul 26;9(8).
  24. Brennan-Speranza TC, Mor D, Mason RS, Bartlett JR, Duque G, Levinger I, Levinger P. Skeletal muscle vitamin D in patients with end stage osteoarthritis of the knee. J Steroid Biochem Mol Biol. 2017 Oct;173:180-184.
  25. Boyan BD, Hyzy SL, Pan Q, Scott KM, Coutts RD, Healey R4, Schwartz Z. 24R,25-Dihydroxyvitamin D3 Protects against Articular Cartilage Damage following Anterior Cruciate Ligament Transection in Male Rats. PLoS One2016 Aug 30;11(8):e0161782.

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